The societal effects of therapies that successfully extend healthspan and/or lifespan are also considered. His group aims to understand how, when, and where critical components of the blood-brain barrier become dysfunctional preceding dementia and in the earliest stages of age-related cognit, In the third installment in a series of episodes, The Knowledge Project curates essential segments from five guests revolving around one theme: leadership. We can all learn from unwelcome challenges and, more often than not, become better as a result of them. (0:24:00) Evidence that Fasting can Attenuate Human Disease He takes it for a cardiovascular condition that is common in his family. (0:08:04) Caloric Restriction is an Evolutionarily Conserved Anti-Aging Strategy (00:07:38) Ex-differentiation as a Driver of Aging Each week Ill be featuring inspirational stories and practical tips from some of my former guests. Humans have the capacity for incredible benevolence and kindness, but also are able to be execute other members of our species with a , Futuristic Researcher Sadiki Bakari takes over our classroom to update us on the latest A. I Artificial Intelligence developments. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. And, just kind of walk away, leaving something that couldve been amazing unfinished? * Twitter "David is a superb Information / Cyber-security executive in every respect. Join Dr. David Sinclair, Ph.D. in Lifespan, a popular health podcast that brings the cutting edge of aging and longevity science straight to you. In this weeks episode, Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. In 2022 Ashley put together an international team to investigate the mysterious origins of a 400 year old light phenomenon in rural Colombia. (00:35:33) Ex-Differentiation David sinclair diet and exercise beastiality sex pics maid pro. They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. Our Patreon page: https://www.patreon.com/davidsinclair The Science of Keeping the Brain Healthy | Episode 7. * InsideTracker - https://insidetracker.com/sinclair They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. Lifespan book: https://amzn.to/3sUqurT (00:37:31) Exercise Recommendations (00:49:30) "No Law That Says We Have To Age" The potential for addiction is everywhere in our society, and on this episode of The Knowledge Project psychiatrist and author Dr. Anna Lembke discusses, On President's Day, Howard University Political Science professor Clarence Lusane checks into our classroom. (00:58:36) Subscription and Support Options (00:10:45) Aging is a Controllable Process that can be Slowed & Reversed 255 talking about this. Season 1 will be 8 episodes in total and will launch on Wednesday, January 5, 2022. In the final episode of this season, Dr. David Sinclair and Matthew LaPlante focus on current and near-future technologies relevant to health and aging. Key takeaways: Dr. David Sinclair's core principles for aging and longevity include diet, exercise, and fasting. Leave your condolences to the family on this memorial page or send flowers to show you care. (00:56:11) Longer Life, Population Size, and Economics Thank you to our sponsors: (1:07:23) Subscription and Support * Athletic Greens - https://athleticgreens.com/sinclair Interviews in Health/Life Sciences/BioTech Entrepreneurship, AI, WEB3 and Policy | Get in touch: pod@musty.io, The Knowledge Project Podcast is a rare opportunity to listen to the best in the world on every topic. (0:13:10) NAD+ is Elevated by a Low Energy State * Athletic Greens - https://athleticgreens.com/sinclair (00:02:54) Estrogen, Progesterone, and Menopause * Athletic Greens - https://athleticgreens.com/sinclair Packed with inspiring stories of resilience, cutting-edge wellbeing revelations, and how each would make the world a happier place if made global dictator for the day. (00:30:57) Sirtuin Proteins as Epigenetic Regulators of Aging Season 1 will be 8 episodes in total and will launch on Wednesday, January 5, 2022. Timestamps: (01:09:25) Subscription and Support Options Love your show, please bring back another season. In Episode 3 of the Lifespan Podcast, Dr. David Sinclair and Matthew LaPlante dive deeply into the science of non-dietary interventions that mimic adversity and promote health. (00:39:28) Wearables and Individualized Health Tracking The 54-year-old Fremont, California native, who covers music, celebrities, and pop culture on Wild 94.9 as well as his podcast shows, was last seen at his home in San Francisco at 10pm Thursday,. He is a professor in the Department of Genetics and a co-founder of several biotechnology companies. * Facebook (00:31:56) A Primer on Stem Cells and Yamanaka Factors They discuss the science behind. David Sinclair Social: Instagram Twitter FacebookMatthew LaPlante's Social: TwitterTo stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.Timestamps:(00:00:00) Introducing Episode Seven: Aging of the Brain(00:04:39) Thanking the Sponsors(00:07:38) Ex-differentiation as a Driver of Aging(00:09:22) The Brain Ages Slowly(00:14:17) Cognitive Function and Plasticity(00:17:44) Three Longevity Pathways: mTOR, AMPK, and Sirtuins(00:23:26) Plant-based Diets and B-vitamins(00:28:32) Homocysteine, Plaque, and Vasculature(00:32:35) Fatty Acids(00:35:48) Physical Activity(00:39:14) Metformin(00:46:02) NAD Boosters(00:50:33) Increasing Blood Flor(00:53:20) Sleep(00:58:02) Overall Message: Keep your Brain Healthy(00:58:50) Next Weeks Episode and the Future of Medicine(01:01:21) Options for Subscription for SupportFor the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. (00:55:19) Frickin Laser Beams: Low-level Laser Therapy Harvard Medical School's Paul F. Glenn Center for Biology of Aging Research. * InsideTracker - https://insidetracker.com/sinclair (00:20:31) Types of Health Sensors (00:58:15) Next Weeks Episode: External Aging Over the last 589 episodes, 1000+ hours and nearly 2000 days of working away on this project I've learned a lot, and today I'm going through some of the most important lessons and, What if you were, unknowingly being controlled by unresolved pain from your past, even minor, or momentary experiences, ones that took root and, from that moment on, without you having any idea, limited everything from your relationships to your health, work, wealth, and life? For Longevity | Episode 5. These chats about repair (our stuff, ourselves and our communities) range from mending textiles to the repair of broken bones, from up-cycling in the pandemic to community conflict in Bangladesh, from home made Punk Clothes to celebrating scars. Copyright 2023 Apple Inc. All rights reserved. About Jobs For the Record. (01:10:45) Subscription & Support (00:17:25) Get Off Your Butt For Longevity | Lifespan With Dr. David Sinclair. Recent pre-print paper - not yet peer reviewed - showing that mice treated with Yamanaka factors lived longer than the control group. In the phase 2 trial, 220 healthy people without obesity dropped their calories significantly, and a test of their biological age showed that their rate of aging slowed by 2 to 3 percent in over a couple of years., John Burroughs, USAF Security Police/Retired. (01:03:06) Putting in the Work for Longevity Previous research on aging and DNA mutations. Episode 2: Poverty, inequa What causes aging? Timestamps: In doing so, they discuss organisms that have extreme longevity, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of "ex-differentiation" in which cells begin to lose their identity, and how all of this makes up the "Information Theory of Aging", and the difference between "biological age" and "chronological age" and how we can measure biological age through DNA methylation clocks. * Levels - https://levels.link/sinclair Before this discussion, Baltimore Relationship Expert Renee Miller. On this episode Sinclair goes in-depth on the process of aging and the techniques you can incorporate into your life that help you live a longer, healthier life, including optimizing your diet, the benefits of exercise, the role of a positive attitude, the importance of . To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com. * Levels - https://levels.link/sinclair * InsideTracker - https://insidetracker.com/sinclair #588 - Dr David Ley - Why Would Any Man Choose To Be Cucked. (00:36:40) Using Personalized Data to Inform your Diet * Twitter In this weeks exciting episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante foray into potential anti-aging interventions that are truly on the cutting edge. For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website. Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. (00:34:45) Autophagy and Retinoids The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. Can you live a good life even when things are hard? As they discuss different adversity mimetics, they also explain how these interventions influence aging at the molecular and physiological levels.Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair Levels - https://levels.link/sinclair InsideTracker - https://insidetracker.com/sinclairOur Patreon page: https://www.patreon.com/davidsinclairTimestamps:(00:00:00) Introducing Episode 3: Exercise Hot Cold(00:01:01) A Pernicisous Element Called Iron(00:02:46) A Quick Primer on Free Radicals(00:05:42) Review of Dietary Takeaways(00:07:01) Sponsors(00:09:32 Biological Adversity & the Survival Circuit(00:13:24) Survival Sensors (i.e., mTOR, AMPK, and Sirtuins) & Communicators (e.g., Insulin)(00:17:25) Get Off Your Butt(00:19:40) Exercise Protects against Disease & Mortality(00:21:17) Daily Step Count and Walking After Eating(00:22:33) Exercise Activates AMPK and Creates More Mitochondria(00:24:03) Vigorous Exercise, Hypoxia, the Electron Transport Chain(00:28:19) Exercise Increases Glucose Sensitivity and Stimulates Blood Vessel Formation(00:32:13) The Epigenome and Biological Age are Impacted by Exercise(00:36:43) How to Measure your Biological Age(00:37:31) Exercise Recommendations(00:39:28) Wearables and Individualized Health Tracking(00:43:14) The Importance of Weight Training(00:46:08) Physical Activity & Senescent Cells(00:48:01) Wrap-up & Takeaways(00:49:47) Hyperbaric Oxygen Therapy(00:57:24) Cold Therapy(01:03:50) Applying Heat(01:07:04) Adversity Mimetics Produce Endorphins(01:08:07) A Basic Protocol for Mimicking Adversity(01:10:04) Next Week: Molecules & Supplements(01:10:45) Subscription & SupportFor the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website. Biotracking, Age Reversal & Other Advanced Health Technologies | Episode 8. 5 years ago on February 12th 2018 I launched this podcast with a conversation in my old company's office in the North East of England. Hear about the latest developments in aging research, lifestyle practices for longevity, exercise and nutrition science, and more. Joe Rogan Experience : aging, epigenome, genetics, healthspan, longevity, metformin, mtor, nad, nmn, rapamycin, resveratrol, sirtuin. They share the latest research surrounding testosterone replacement therapy (TRT), human growth hormone (HGH), peptide supplementation, exosomes, stem cells, and cellular reprogramming. 13:53 There is no growth , It's Modern Wisdom's 5th birthday!! David Sinclair Social: Instagram Twitter FacebookTo stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.Matthew LaPlante's Social: TwitterTimestamps:(00:00:00) Kicking Off Episode Five: Interventions on the Cutting Edge(00:02:39) Expressing Gratitude to the Sponsors(00:05:28) Testosterone Replacement Therapy(00:10:09) Human Growth Hormone(00:13:56) Peptide Supplementation and Regenerative Signaling(00:18:11) MOTS-c, Humanin, and Other Peptides(00:25:05) Exosome Therapy(00:31:56) A Primer on Stem Cells and Yamanaka Factors(00:37:59) Stem Cell Aging and Cord Blood Banking(00:41:42) The Therapeutic Potential of Stem Cells(00:43:37) Cellular Reprogramming(00:51:35) Resetting the Aging Clock(00:56:50) The Future Looks Bright(00:58:15) Next Weeks Episode: External Aging(00:58:36) Subscription and Support OptionsFor the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. 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